February 18 2019
From the news desk of UC San Diego Health: Krishnan Chakravarthy MD, PhD, a pain management specialist at UC San Diego Health and Veterans Affairs San Diego Healthcare System, believes inflammation may be at the [...]
Krishnan Chakravarthy writes in NeuroNews about how spinal cord stimulation can be used to treat chronic pain and how this can help America overcome its opioid epidemic. The statistics are clear, we are amid an [...]
Cancer-related pain affects approximately 9 million people worldwide each year, with the number of new cases expected to increase from 12.7 million in 2008 to 22.2 million by 2030.1,2 Cancer pain has been linked to [...]
Dr Krishnan Chakravarthy will be speaking at Drug Delivery West at the Mark Hopkins Intercontinental Hotel in San Francisco in May. About the Event: The PODD teams bring to the West Coast a Drug Delivery [...]
Dr Krishnan Chakravarthy will be speaking at the SBMT 15th Annual Congress - Millennium Biltmore Hotel in LA in April. The 15th Annual World Congress of SBMT will bring together physicians, scientists, policy makers, funding [...]
Lung viral and bacterial infections, like influenza and pneumonia, could be prevented through inhaled anaesthetics commonly used in surgeries, scientists suggest. New experiments have proven that the volatile anaesthetics, nitrous oxide and halothane, have powerful [...]
Certain so-called "volatile" anaesthetics -- commonly used during surgeries -- may also possess powerful effects on the immune system that can combat viral and bacterial infections in the lung, including influenza and pneumonia, say researchers, including one of Indian-origin. [...]
A Buffalo nanomaterials firm is hoping a new investment deal will help it accelerate product development and commercialization efforts. NanoAxis LLC is a six-year-old firm that focuses on using nanomaterials for various biomedical applications related [...]
About Chakravarthy Lab
“Right now we absolutely have everything in our hands to revolutionize medicine. I can imagine in 20 years being able to cure all diseases at the genetic level with nanotechnology. It’s mind-boggling. The industry is now at the cutting edge” Dr Krishnan Chakravarthy
The primary goals of the Chakravarthy Lab are to investigate the pathophysiology and mechanisms of chronic pain in the context of complex regional pain syndrome (CRPS), diabetic neuropathy, persistent postsurgical pain and neuropathic pain. Further, our lab focuses on how volatile anesthetics and various pain modulators affect host immunity to viral and bacterial infections.
The four core areas of active investigation include:
1. Basic Mechanisms of Chronic Pain
At present we are specifically studying the role of caveolins, inflammatory cytokine mediators (TLR4), and mitochondria in the pathogenesis of chronic pain in settings of complex regional pain syndrome, neuropathic pain, persistent post-operative pain, traumatic brain injury (TBI), and diabetic neuropathy.
2. Infectious Diseases
We focus here on the effects of volatile anesthetics toward the mitigation of susceptibility to secondary bacterial pneumonia in post-influenza viral infection: Our laboratory is studying, via a mouse model, the impacts of volatile anesthetics and their ability to down-modulate the type 1 interferon (IFN) response to influenza infection, which results in an increased antibacterial response to secondary bacterial pneumonia.
Based on the deduced mechanisms of how volatile anesthetics function, we are currently working to develop small molecule candidates as alternative vaccine and antibiotic treatments against seasonal and pandemic influenza.
This project is currently being done in conjunction with the US Center for Disease Control.
Currently, our laboratory is working to employ various nanomaterials and biodegradable nanosystems to create novel point of care diagnostics and targeted drug delivery strategies, for the treatment of various chronic pain states, and in infectious disease applications. To these ends we are actively collaborating with the UCSD Department of Nanoengineering.
The Chakravarthy Lab is also collaborating with the UCSD Integrated Electronics and Bio Interfaces Laboratory to develop new and advanced spinal cord neuromodulation devices for the management of chronic pain.